-5%
Initer is a recombinant form of human erythropoietin (EPO), expressed in Chinese hamster ovary cells. Its amino acid sequence is identical to that of human urinary EPO, with a molecular weight of approximately 30,400 daltons.
Initer is indicated for the treatment of anemia in various conditions:
Anemia Associated with Chronic Renal Failure (CRF):
- Patients on dialysis (End-Stage Renal Disease, ESRD): To reduce the need for red blood cell (RBC) transfusions.
- Patients not on dialysis: For anemia in chronic kidney disease (CKD), where hemoglobin levels are below 10 g/dL, and there is a risk of RBC transfusions or alloimmunization.
Zidovudine-Related Anemia:
- Treatment for anemia in HIV-infected patients receiving zidovudine therapy (administered at <4200 mg/week) with low endogenous serum erythropoietin levels.
Chemotherapy-Related Anemia:
- Treatment of anemia in non-myeloid malignancy patients, especially when caused by myelosuppressive chemotherapy (for >2 months).
Anemia in Patients Undergoing Surgery:
- For elective, non-cardiac, non-vascular surgeries to reduce the need for alloge neic RBC transfusions, in patients with a hemoglobin level of 10-13 g/dL.