-2%
Omeprazole is a substituted benzimidazole and a potent proton pump inhibitor (PPI) that suppresses gastric acid secretion. It acts by selectively inhibiting the H⁺/K⁺-ATPase enzyme system in the parietal cells of the stomach — the final step in acid production.
After oral administration, acid suppression begins within one hour, reaches its peak in two hours, and may last up to 72 hours. Normal acid secretion resumes gradually within 3 to 5 days after discontinuation.
Inpro (Omeprazole)|Oral Administration
Benign gastric & duodenal ulcer:
20 mg once daily for 4 weeks (duodenal) or 8 weeks (gastric); may increase to 40 mg if necessary. Maintenance dose: 20 mg daily; prophylaxis: 10–20 mg daily.
NSAID-associated ulcers:
20 mg daily for 4 weeks (extend to 8 weeks if required). For prophylaxis, 20 mg once daily.
GERD:
20 mg daily for 4–8 weeks; in resistant cases, 40 mg daily for 8 weeks. Maintenance dose: 20 mg daily.
Long-term acid reflux management: 10–20 mg daily.
Acid-related dyspepsia: 10–20 mg daily for 2–4 weeks.
Prophylaxis of acid aspiration: 40 mg the night before and another 40 mg 2–6 hours before surgery.
Zollinger–Ellison syndrome:
Start with 60 mg once daily; adjust individually (range 20–120 mg/day). Doses above 80 mg should be divided.
H. pylori eradication:
20 mg twice daily with:
Amoxicillin 500 mg + Metronidazole 400 mg three times daily for 1 week, or
Clarithromycin 250 mg + Metronidazole 400 mg twice daily for 1 week, or
Amoxicillin 1 g + Clarithromycin 500 mg twice daily for 1 week.
Pediatric (≥1 year, severe reflux esophagitis):
10–20 kg: 10–20 mg daily for 4–12 weeks
20 kg: 20–40 mg daily for 4–12 weeks