-2%
Chronic Constipation:
For chronic constipation, initial management should focus on lifestyle modifications such as a high-fiber diet (including vegetables, fruits, and salads), adequate fluid intake, and regular physical activity. Lactu should be used only when these measures fail to provide sufficient relief.
Disturbances of Intestinal Flora:
Lactu may be beneficial in restoring normal intestinal flora, particularly following prolonged antibiotic therapy.
Other Indications:
- Gallbladder disorders
- Intestinal diseases (e.g., colitis, diverticulosis, megacolon)
Elevated blood ammonia levels are associated with hepatopathy or portal-systemic encephalopathy
Lactu is a hyperosmolar laxative used effectively for the management of constipation. It contains lactulose, a non-absorbable disaccharide that draws water into the bowel lumen, leading to stool softening and stimulation of bowel movements through increased intestinal distention.
Lactulose is a synthetic disaccharide that undergoes metabolism in the colon by saccharolytic bacteria, producing low-molecular-weight organic acids (mainly lactic acid). These acids reduce colonic pH and retain water via osmotic action, thereby enhancing peristaltic activity and promoting defecation.
Since lactulose is minimally absorbed, its systemic pharmacokinetics are not relevant to its therapeutic effect.