-2%
Lornoxicam belongs to the oxicam group of NSAIDs. It works mainly by inhibiting cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins responsible for pain and inflammation. This helps decrease pain, swelling, and inflammation in affected joints and tissues.
Loxodol contains lornoxicam, a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of acute pain and for relieving pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
The dose should be individualized according to the condition and response to treatment.
Acute pain
- 8–16 mg daily, divided into 2 or 3 doses
- Maximum recommended daily dose: 16 mg
Osteoarthritis and rheumatoid arthritis
- Initial dose: 12 mg daily, divided into 2 or 3 doses
- Maintenance dose should not exceed 16 mg daily
Children and adolescents
Lornoxicam is not recommended for individuals below 18 years because adequate safety and efficacy data are not available.
Elderly patients
No routine dose adjustment is generally required in patients over 65 years. However, extra caution is advised because older adults may be more susceptible to gastrointestinal complications.
Renal impairment
For mild to moderate kidney impairment, the maximum recommended dose is 12 mg daily, divided into 2 or 3 doses.
Hepatic impairment
For moderate liver impairment, the maximum recommended dose is 12 mg daily, divided into 2 or 3 doses.
The lowest effective dose for the shortest necessary duration should be used to reduce the risk of adverse effects.
Drug Interactions
Loxodol may interact with several medicines, including:
- Warfarin and other vitamin K antagonists: May increase the risk of bleeding.
- Cyclosporine: May increase the risk of kidney impairment or acute kidney injury.
- Lithium: Lornoxicam may increase lithium levels and toxicity.
- Methotrexate: May increase methotrexate-related adverse effects.
- Digoxin: May increase digoxin exposure.
- Diuretics: Their effects may be reduced, and kidney function may be affected.
- ACE inhibitors and angiotensin II receptor blockers (ARBs): Their blood-pressure-lowering effect may be reduced, particularly in patients with heart failure.
Tell your doctor about all prescription medicines, over-the-counter medicines, and supplements you use before starting Loxodol.
Contraindications
Loxodol should not be used in patients with:
- Allergy or hypersensitivity to lornoxicam or its ingredients
- Active or previous peptic ulcer disease
- Severe liver impairment
- Severe kidney impairment
- Thrombocytopenia
- Pregnancy, particularly the third trimester
Side Effects
NSAIDs such as lornoxicam can commonly cause gastrointestinal side effects, including:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Flatulence
- Indigestion
- Abdominal pain
- Gastric or peptic ulcers
- Gastrointestinal bleeding
- Black, tarry stools (melena)
- Vomiting blood (hematemesis)
- Ulcerative stomatitis
- Worsening of ulcerative colitis or Crohn’s disease
Serious gastrointestinal bleeding, ulceration, or perforation can occur and may occasionally be life-threatening, particularly in older adults.
Pregnancy & Lactation
Lornoxicam should not be used during pregnancy unless specifically advised by a doctor and is contraindicated during the third trimester. It should also be avoided during labor and delivery.
There is insufficient information regarding the presence of lornoxicam in human breast milk. Because animal studies indicate significant transfer into milk, breastfeeding women should not use lornoxicam unless specifically advised by a healthcare professional.
Precautions & Warnings
Use Loxodol cautiously if you have:
- Kidney problems
- High blood pressure
- Heart failure
- A history of stomach ulcers or gastrointestinal bleeding
- Ulcerative colitis or Crohn’s disease
- A bleeding disorder or tendency to bleed
- Asthma
- Systemic lupus erythematosus (SLE)
- Fertility problems or are receiving treatment for infertility
Avoid taking more than the prescribed dose. Prolonged or high-dose NSAID use can increase the risk of gastrointestinal, kidney, and cardiovascular complications.
Overdose
Taking more Loxodol than prescribed may cause:
- Nausea
- Vomiting
- Dizziness
- Visual disturbances
- Other central nervous system symptoms
If an overdose is suspected, seek immediate medical attention. There is no specific antidote for lornoxicam. Treatment is generally supportive.
Therapeutic Class
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Store below 30°C, protected from light and moisture. Keep out of the reach and sight of children.