-5%
Macipah 10 Tablet is used in the treatment of Pulmonary arterial hypertension (PAH) in adults. The detailed uses of Macitent Tablet are as follows:
- Pulmonary Arterial Hypertension (PAH): Macipah 10 Tablet helps lower pressure in the lung arteries, making it easier for the heart to pump blood through the lungs.
- Improves Exercise Capacity: Macipah 10 Tablet can enhance physical endurance and delay disease progression.
Endothelin-1 (ET-1) and its receptors (ETA and ETB) play a significant role in pathological processes such as vasoconstriction, fibrosis, cellular proliferation, hypertrophy, and inflammation. In PAH, the endothelin system is overactive, contributing to vascular remodeling and organ damage.
Macitentan is a dual endothelin receptor antagonist that blocks the binding of ET-1 to both ETA and ETB receptors. It demonstrates high receptor affinity and prolonged receptor occupancy in pulmonary arterial smooth muscle cells. One of its metabolites is pharmacologically active and exhibits approximately 20% of the parent drug’s potency in vitro. The clinical significance of dual endothelin receptor blockade remains uncertain.