-5%
Megestrol Acetate is a synthetic antineoplastic and progestational agent. The exact mechanism of its antineoplastic activity in endometrial carcinoma is unclear but may involve:
- Inhibition of pituitary gonadotropin secretion, leading to reduced estrogen production.
- Direct cytotoxic effects on tumor cells and modification of steroid hormone activity in breast cancer.
In metastatic cancers, hormone receptors may vary across tissues. Estrogen binds to cytoplasmic receptors in target cells, enters the nucleus, and triggers gene transcription, altering cell behavior. Megestrol Acetate in pharmacological doses:
- Reduces hormone-dependent human breast cancer cell populations.
- Counteracts estrogen’s stimulatory effects on these cells.
