-5%
Generic Name: Moxifloxacin Hydrochloride 400mg
Manufacturer: Incepta Pharmaceuticals Ltd.
Indications
Moxifloxacin is used to treat acute bacterial sinusitis, acute aggravation of chronic bronchitis, community-acquired pneumonia, simple and difficult skin and skin structure infections, complex intra-abdominal infections, and pelvic inflammatory disease.
Pharmacology
Moxifloxacin is a fluoroquinolone-class antibacterial medication of the fourth generation. It is active against a wide spectrum of microorganisms, including Mycoplasma pneumonia, that is gram-positive, gram-negative, anaerobic, or atypical. It works by blocking topoisomerases II (DNA gyrase) and IV, which are required for bacterial DNA replication, transcription, and repair.
Dosage & Administration
Acute bacterial sinusitis: 400 mg once daily for 7-10 days.
Acute bacterial exacerbation of chronic bronchitis: 400 mg once daily for 5-10 days.
Community-acquired pneumonia: 400 mg once daily for 7-14 days.
Uncomplicated skin and skin structure infections: 400 mg once daily for 7 days.
Complicated skin and skin structure infections: 400 mg once daily for 7-21 days.
Complicated intra-abdominal infections: 400 mg once daily for 5-14 days.
Pelvic inflammatory disease: 400 mg once daily for 14 days.
Interaction
When antacids, sucralfate, multivitamins, and multivalent cations are combined with moxifloxacin, absorption is reduced (e.g. iron or zinc). Moxifloxacin may increase the risk of seizures when used with NSAIDs and bleeding when combined with warfarin. As a result, using Moxifloxacin with them should be avoided.
Contraindications
It is not recommended for individuals who have previously had hypersensitivity to Moxifloxacin or other quinolones.
Side Effects
Nausea, vomiting, diarrhea, headache, and dizziness are common adverse effects of Moxifloxacin.
Pregnancy & Lactation
Pregnancy category C according to the US Food and Drug Administration. Moxifloxacin is not advised to be used during pregnancy or breastfeeding.
Precautions & Warnings
Moxifloxacin may increase the likelihood of tendinitis and tendon rupture. It should be stopped if there is discomfort or inflammation in a tendon. It should not be used in patients who have a known QT interval prolongation, patients who have uncorrected hypokalemia, or patients who are receiving Class IA or Class III antiarrhythmic medicines.
Storage Conditions
Store in a cool, dry area away from light and heat. Keep out of children’s reach.