-5%
Osteoarthritis
Osteoarthritis is a joint disorder that occurs when the protective cartilage covering the bone ends wears away. Without this cushioning, the bones rub directly against each other, leading to pain, stiffness, and reduced mobility. Common symptoms include pain, stiffness, swelling, inflammation, and tenderness.
Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune condition in which the body’s immune system mistakenly attacks its own tissues, primarily affecting the joints. This results in pain, swelling, stiffness, joint deformities, and loss of joint function
Dosage
Adults
Osteoarthritis: Start with 1 g orally once daily. Maintenance dose: 1–2 g per day, either as a single daily dose or split every 12 hours. Do not exceed 2 g daily.
Rheumatoid arthritis: Start with 1 g orally once daily. Maintenance dose: 1–2 g per day, as a single daily dose or in divided doses every 12 hours. Maximum dose 2 g daily.
Elderly patients: Some may respond to 500 mg daily, with a maximum of 1 g daily.
Children
Not recommended.
Renal Impairment
CrCl 30–49 ml/min: Initial dose 750 mg once daily, may be increased up to 1.5 g daily if needed.
CrCl <30 ml/min: Initial dose 500 mg once daily, maximum 1 g daily.