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Olmenor Plus 5/40mg contains Amlodipine Besilate 5mg + Olmesartan Medoxomil 40mg — a dual-action antihypertensive tablet by Drug International Ltd. Amlodipine (calcium channel blocker) relaxes peripheral blood vessels; Olmesartan (ARB) blocks the angiotensin II AT1 receptor — providing superior, sustained blood pressure control compared to either agent alone.
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For adults with hypertension inadequately controlled on monotherapy. উচ্চ রক্তচাপ নিয়ন্ত্রণে শক্তিশালী দ্বৈত সমন্বয় থেরাপি।
Olmenor Plus 5/40mg — Amlodipine Besilate 5mg + Olmesartan Medoxomil 40mg
Olmenor Plus 5/40mg is a fixed-dose combination antihypertensive tablet containing Amlodipine Besilate 5mg (a dihydropyridine calcium channel blocker) and Olmesartan Medoxomil 40mg (an angiotensin II receptor blocker — ARB), manufactured by Drug International Ltd. — a leading pharmaceutical company in Bangladesh.
The two complementary mechanisms of action make Olmenor Plus significantly more effective than either drug alone at equivalent doses, with better tolerability (Amlodipine-associated oedema is reduced when combined with an ARB).
Indications (Uses)
- Hypertension (high blood pressure) in adults whose blood pressure is not adequately controlled on monotherapy
- Hypertension with concurrent type 2 diabetes (renal-protective benefits of ARB)
- Hypertension in patients at high cardiovascular risk (post-MI, chronic kidney disease)
- Reduction of risk of fatal and non-fatal cardiovascular events in hypertensive patients
Mechanism of Action (Pharmacology)
Amlodipine (CCB): Blocks L-type voltage-gated calcium channels in vascular smooth muscle and cardiac cells, causing arterial vasodilation and reducing peripheral vascular resistance — lowering systolic and diastolic blood pressure.
Olmesartan Medoxomil (ARB): Selectively blocks the AT1 angiotensin II receptor, preventing angiotensin II-mediated vasoconstriction, aldosterone secretion, and sodium retention. This independently lowers blood pressure and provides organ-protective effects.
Dosage & Administration
- Adults: 1 tablet (5/40mg) once daily, with or without food
- Standard starting dose: Amlodipine 5mg + Olmesartan 20mg once daily; titrate to 5/40mg after 1–2 weeks if needed
- Maximum dose: Amlodipine 10mg + Olmesartan 40mg once daily
- Take at the same time each day for consistent blood pressure control
Contraindications
- Pregnancy (2nd and 3rd trimesters) — Olmesartan can cause fetal renal dysfunction and death
- Concomitant use with aliskiren in patients with diabetes
- Severe hepatic impairment
- Known hypersensitivity to Amlodipine, Olmesartan, or dihydropyridines
Side Effects
Common: Peripheral oedema (ankle/foot swelling), dizziness, headache, flushing, fatigue.
Uncommon: Hypotension (especially on first dose or if dehydrated), palpitations.
Rare but serious: Sprue-like enteropathy (severe chronic diarrhoea with weight loss — discontinue and seek medical attention), angioedema.
Drug Interactions
- Potassium-sparing diuretics / potassium supplements: Risk of hyperkalaemia with ARBs
- NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and increase renal impairment risk
- Lithium: ARBs may increase serum lithium levels — monitor closely
- Dual RAAS blockade (ACE inhibitors + ARB): Not recommended — increased risk of hypotension, hyperkalaemia, and renal impairment
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Substitute Brands in Bangladesh
Other Amlodipine+Olmesartan brands in Bangladesh: Olmezest AM (Sun Pharma), Olmedip (Ibn Sina), Orbapin (Popular Pharma), Olmetor AM (Euro Pharma). Consult your doctor before switching brands.
Consult your doctor or pharmacist before starting or changing your blood pressure medication. Never stop antihypertensive therapy without medical advice.