-5%
Omega-3-acid ethyl esters lower triglyceride levels by reducing production in the liver, though the exact mechanism is not fully understood. This medication:
- Inhibits acyl-CoA: 1,2-diacylglycerol acyltransferase, decreasing triglyceride synthesis.
- Increases paroxysmal beta-oxidation, enhancing fatty acid metabolism.
- Competes with enzymes involved in triglyceride synthesis, thereby reducing fatty acid release.
- Boosts triglyceride clearance by increasing lipoprotein lipase activity.
- Decreases production of very-low-density lipoprotein cholesterol (VLDL-C).
