-2%
The biologically active form of Vitamin D3, Calcitriol, exerts its effects by binding to Vitamin D receptors (VDRs) present in various body tissues.
Being fat-soluble, Vitamin D3 has an approximate half-life of 50 days. It is absorbed in the small intestine, binds to alpha-globulins, and is transported to the liver, where it is converted into 25-hydroxy Vitamin D3 (Calcidiol).
A subsequent hydroxylation in the kidneys produces 1,25-dihydroxy Vitamin D3 (Calcitriol), the active metabolite responsible for promoting calcium absorption.
Unmetabolized Vitamin D3 is stored mainly in fat and muscle tissues and excreted through urine and feces.
Vitamin D3 deficiency may occur in individuals with limited exposure to sunlight or inadequate dietary intake of Vitamin D3.
Ortho-D3 plays a vital role in promoting effective calcium and phosphate absorption, ensuring healthy bone and teeth formation, and preventing rickets, osteomalacia, and osteoporosis.
It is also essential during pregnancy and lactation to help prevent pre-eclampsia and support healthy growth and immune function in infants.
Additionally, Ortho-D3 contributes to enhancing immune defense and overall well-being.