-2%
Selomet is used in the management of:
- Hypertension
- Angina pectoris
- Cardiac arrhythmias (especially supraventricular tachyarrhythmias)
- Hyperthyroidism (as adjunct therapy)
- Acute myocardial infarction: Early administration can help reduce infarct size, lower the risk of ventricular fibrillation, and reduce the need for opioid analgesics. Clinical data also shows a reduction in mortality in acute MI patients.
Metoprolol is a selective beta1-adrenergic receptor blocker that diminishes the effects of catecholamines (e.g., adrenaline) on the heart. It reduces heart rate, myocardial contractility, and blood pressure, particularly during stress. Unlike non-selective beta-blockers, metoprolol has minimal interference with insulin secretion and less effect on hypoglycemia-induced cardiovascular responses, making it safer for diabetic patients.Â
Overdosage Symptoms: Severe hypotension, AV block, bradycardia, cardiogenic shock, coma, bronchospasm, hypoglycemia.
Management: Supportive care, activated charcoal if recent ingestion, use of sympathomimetics (e.g., dopamine, norepinephrine), atropine, glucagon (1–10 mg IV), pacing, and β2 agonists for bronchospasm. Hemodialysis is ineffective.