Sertal 100mg 10Pcs

Indications

Sertal is indicated for the treatment  of symptoms of depressive illness, including  accompanying symptoms of anxiety. Following  satisfactory response continuation with Sertal  therapy is effective in preventing relapse of the  initial episode of depression or recurrence of further  depressive episodes, including accompanying  symptoms of anxiety.

Pharmacology

Sertraline has a potent and selective inhibitory effect on neuronal 5HT reuptake in the CNS, leading to increased concentrations of 5HT at the synaptic cleft, facilitating its sustained activity at the synaptic cleft. postsynaptic receptor sites. This ultimately leads to an improvement in depression. Another contributing factor related to its activity is the reduction of serotonin turnover in the brain by sertraline. Its extended half-life offers the advantage of once-daily dosing.

Dosage & Administration

Dosage for Adult : Major Depressive Disorder and Obsessive-Compulsive Disorder-Sertal treatment should be  administered at a dose of 50mg once daily. Panic  Disorder, Posttraumatic Stress Disorder and Social Anxiety Disorder- Sertal treatment should be  initiated with a dose of 25mg once daily. After one  week, the dose should be increased to 50mg once  daily. Prementstrual Dysphoric Disorder- Sertal  treatment should be initiated with a dose of  50mg/day, either daily throughout the menstrual  cycle or limited to the luteal phase of the menstrual  cycle, depending on physician assessment.

Dosage for Pediatric Population : Sertal  treatment should be initiated with a dose of 25mg  once daily in children (ages 6-12) and at a dose of  50mg once daily in adolescents (ages 13-17).  Sertal should be administered once daily, either in  the morning or evening. Or as directed by the  physician.

Interaction

Monoamine oxidase inhibitor: Sertal should not be used in combination with a  MAOI or other centrally active medication. since  Sertal is bound to plasma protein, the potential of Sertal to interact with other plasma protein bound  drugs should be borne in mind. Co-administration of Sertal with warfarin resulted in a small but  statistically significant increase in prothrombin  time, the clinical significance of which is  unknown. Accordingly prothrombin time should be  carefully monitored when Sertal therapy is  initiated or stopped.

Contraindications

Sertal is contraindicated in  patients with a known hypersensitivity to  sertraline.

Side Effects

The side effects are hypertension,  tachycardia, dizziness, postural hypotension,  peripheral edema, hypotension, leg cramps,  pruritus, acne, dry skin, back pain, anemia etc.

Pregnancy & Lactation

Use in patients with renal or  hepatic impairment : As with many other  medications, sertraline should be used with caution  in patients with renal and hepatic impairment.

Precautions & Warnings

There are no adequate and well controlled studies in pregnant women, since animal reproduction studies are not always predictive of human response. Sertal should be used during pregnancy only if the perceived benefits outweigh the risks. Limited data concerning sertraline levels in breast milk are available, hence it is not recommended in nursing mother. Pregnancy Category C by FDA.

Therapeutic Class

SSRIs & related anti-depressant drugs

Storage Conditions

Do not store above 30°C. Keep out of the reach of children.