-5%
Sitagliptin + Metformin Hydrochloride is used as an adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus, particularly when treatment with both sitagliptin and metformin is appropriate.
It should not be used in patients with type 1 diabetes or for diabetic ketoacidosis, as it would not be effective in these conditions. It has not been studied in patients with a history of pancreatitis, and the risk of pancreatitis in these patients is unknown.
Sliptin-M 1000 ER Tablet combines two antihyperglycemic agents with complementary mechanisms. Sitagliptin, a DPP-4 inhibitor, works by prolonging the activity of incretin hormones like GLP-1 and GIP, which increase insulin secretion and reduce glucagon levels in a glucose-dependent manner. Metformin, a biguanide, lowers blood glucose by reducing hepatic glucose production, decreasing intestinal glucose absorption, and increasing peripheral glucose uptake.