-2%
Cefradine, a first-generation cephalosporin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing the final transpeptidation step of peptidoglycan synthesis. This results in cell wall disruption and bacterial cell death. Supracef may be taken with or without food; however, taking it with meals can help minimize gastrointestinal discomfort.
Supracef is indicated for the treatment of pneumonia, pharyngitis, tonsillitis, otitis media, respiratory tract infections, urinary tract infections, skin and soft tissue infections, rheumatic fever, genitourinary infections, acute prostatitis, and for surgical prophylaxis against susceptible bacterial infections.
Adults:
Oral (PO): 1–2 g daily in 2–4 divided doses (maximum 4 g/day).
Surgical prophylaxis: 1–2 g before surgery; additional doses may be administered as required.
Skin/Respiratory infections: 250 mg every 6 hours or 500 mg every 12 hours.
Pneumonia: 500 mg every 6 hours or 1 g every 12 hours.
UTI: 500 mg every 12 hours.
GI infections: 500 mg three to four times daily.
IV/IM (severe infections): 2–4 g/day in four divided doses (maximum 8 g/day).
Children:
Oral: 25–50 mg/kg/day in 2–4 divided doses.
Injection: 50–100 mg/kg/day in four divided doses (may increase to 200–300 mg/kg/day in severe infections).
Surgical prophylaxis: 1–2 g via IM/IV route followed by additional doses as needed.
Renal Impairment:
CrCl >20 mL/min: 500 mg every 6 hours.
CrCl 5–20 mL/min: 250 mg every 6 hours.
CrCl <5 mL/min: 250 mg every 12 hours.
Hemodialysis: 250 mg at the start of dialysis, repeated 6–12 hours later, then 36–48 hours after the initial dose, and again at the next dialysis session if >30 hours have passed.