-2%
Tamoxifen, a triphenylethylene derivative, works by:
- Binding competitively to estrogen receptors on tumors and other tissues.
- This prevents estrogen from stimulating cancer cell growth.
- Decreasing DNA synthesis, thereby reducing the tumor’s ability to grow.
- Acting as a cytostatic agent (slowing cell division) rather than cytotoxic, leading to an accumulation of cancer cells in the G0 and G1 phases of the cell cycle.
- Tamiren helps treat breast cancer and reduces the risk of recurrence or cancer in the other breast.
- Inform your doctor if you notice irregular periods or heavier bleeding.
- Do not stop taking Tamiren without consulting your doctor.
- Tamiren can reduce the effectiveness of birth control pills. Use reliable barrier contraceptives (e.g., condoms) while taking it and for 2 months after stopping the medication.
