-5%
Tamoxen is prescribed for the treatment of breast cancer.
Tamoxifen is a non-steroidal selective estrogen receptor modulator (SERM). It binds to estrogen receptors (ER), altering their structure and blocking or modifying the transcription of estrogen-responsive genes. This action leads to reduced DNA polymerase activity, decreased thymidine uptake, inhibited estradiol binding, and reduced estrogen response. Depending on the tissue, Tamoxifen can exert both estrogenic and anti-estrogenic effects by interacting with coactivators or corepressors and binding to ER-alpha or ER-beta receptors.