-5%
Amlodipine 5mg + Atenolol 25mg | This preparation combines Amlodipine (a calcium channel blocker) and Atenolol (a beta-blocker) for synergistic control of blood pressure and cardiac workload.
Amlodipine:
- A dihydropyridine calcium channel antagonist that inhibits calcium influx in vascular smooth muscle and cardiac muscle
- Acts predominantly on vascular smooth muscle, causing vasodilation and reduced peripheral resistance
- Decreases coronary vasoreactivity, lowers afterload, and reduces cardiac oxygen demand
Atenolol:
- A cardioselective beta-blocker (selectivity is dose-dependent)
- Lowers blood pressure by reducing cardiac output, suppressing plasma renin activity, and decreasing sympathetic outflow
- Provides cardioprotection by reducing myocardial oxygen demand through negative inotropic and chronotropic effects
Tenocab 25 | Amlodipine 5mg + Atenolol 25mg
This fixed-dose combination is prescribed for:
- Patients with essential hypertension
- Patients with angina pectoris and hypertension occurring together
- Post-myocardial infarction (MI) patients
- Patients with refractory angina pectoris unresponsive to nitrate therapy
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Pharmacology
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Pregnancy & Lactation
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Therapeutic Class
Combined antihypertensive preparation
