-2%
Trepmac 90mg Tablet is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic Non-Small Cell Lung Cancer (NSCLC) who have progressed on or are intolerant to Crizotinib.
Brigatinib is used to treat a specific type of non-small cell lung cancer (NSCLC) that has metastasized to other parts of the body. It belongs to a class of medications called kinase inhibitors, working by blocking the action of an abnormal protein that signals cancer cells to multiply, thus slowing or halting the spread of cancer cells.
- Brigatinib is administered orally as a tablet, usually once daily, with or without food.
- Take it at the same time each day.
- Swallow tablets whole; do not chew or crush.
- In case of vomiting after taking the medication, do not take an additional dose; continue with the regular dosing schedule.
- The initial low dose increased after 7 days of treatment.
- Do not stop taking it without consulting your doctor.
Before taking brigatinib, inform your healthcare provider about:
- Allergies to brigatinib or its ingredients.
- Other medications, including prescription, non-prescription, vitamins, supplements, and herbal products.
- Conditions such as high blood pressure, slow heartbeat, diabetes, kidney or liver disease.
- Pregnancy plans for pregnancy, or breastfeeding.
Brigatinib may interfere with hormonal contraceptives. Use non-hormonal birth control methods during treatment. Females should use non-hormonal contraception during treatment and for 4 months after the final dose. Males and their partners should use birth control during treatment and for 3 months after the final dose.
- Avoid grapefruit and grapefruit juice while taking brigatinib.
- Skip the missed dose and continue the regular schedule.
- If brigatinib is not taken for 14 days or longer, consult with your doctor before restarting.
Common side effects may include nausea, diarrhea, vomiting, tiredness, rash, headache, numbness or pain in hands or feet, joint or back pain, loss of appetite, and difficulty sleeping. Serious side effects may include difficulty breathing, chest pain, persistent cough, fever, severe headache, blurred vision, extreme thirst, frequent urination, muscle pain or weakness, and slow or irregular heartbeat.
- Report any severe or unusual symptoms to your doctor promptly.
- Serious side effects should be reported to the FDA’s MedWatch Adverse Event Reporting program.