-2%
This combination of Frusemide and Spironolactone is prescribed for the treatment of:
- Primary (essential) hypertension
- Chronic heart failure with fluid retention
- Liver cirrhosis with abdominal fluid accumulation (ascites)
- Generalized edema caused by fluid overload
- Hyperaldosteronism (excess aldosterone production)
- Persistent edema linked to secondary hyperaldosteronism
Frusemide (a loop diuretic) and Spironolactone (a potassium-sparing diuretic) have complementary mechanisms that result in enhanced diuretic efficacy.
- Frusemide acts on the ascending limb of the Loop of Henle, blocking the sodium-potassium-chloride (Na⁺/K⁺/2Cl⁻) co-transporter. This prevents the reabsorption of sodium, potassium, and chloride, increasing urine output and causing potassium loss.
- Spironolactone, by antagonizing aldosterone at the distal renal tubule, inhibits sodium reabsorption in exchange for potassium. This reduces potassium loss caused by Frusemide, creating a balanced diuretic action.