-2%
Carbamazepine-
- Seizures:
- Partial and secondary generalized tonic-clonic seizures.
- Primary generalized tonic-clonic seizures.
- Trigeminal Neuralgia: Effective for pain relief.
- Bipolar Disorder: Used as prophylaxis.
- Acts by stabilizing hyperactive neuronal activity, possibly via sodium channel modulation.
- Stimulates antidiuretic hormone (ADH) release and enhances water reabsorption.
Carbamazepine inhibits activity in the thalamic nucleus ventralis, limits synaptic propagation of excitatory impulses, and diminishes the summation of temporal stimuli leading to neuronal discharge by reducing the influx of Na ions across the cell membrane, among other processes. It increases the secretion of antidiuretic hormone (ADH) and enhances its ability to promote water reabsorption.