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ZUNO-SR

SKU: 144692

Manufacturer: Other

Generic: Aceclofenac + Paracetamol + Serrati peptidase

Type: Tablet

Pack Size: 10 Pcs

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Description

Zuno-SR (aceclofenac + paracetamol + serratiopeptidase) is a modern formulation, but its ingredients have decades of medical history:

  • Paracetamol – 145+ years
  • Serratiopeptidase – ~60 years
  • Aceclofenac – ~30 years
    Together, they form a widely used combination for pain, inflammation, and swelling.

Derivative of diclofenac, created to provide similar pain-relieving and anti-inflammatory benefits but with better gastrointestinal tolerability.

proteolytic enzyme originally isolated from Serratia marcescens bacteria in the intestine of silkworms.

History of Zuno-SR (by components)

1. Aceclofenac

Developed: Early 1990s

Origin: A derivative of diclofenac, created to provide similar pain-relieving and anti-inflammatory benefits but with better gastrointestinal tolerability.

Purpose: Designed as a safer NSAID alternative for long-term use in arthritis.

Approval: Became widely used in Europe and Asia for conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

2. Paracetamol (Acetaminophen)

Discovered: 1877

Introduced to medicine: 1950s

Origin: Derived from earlier analgesics (acetanilide, phenacetin).

Reason for popularity:

Effective for pain and fever

Safer than aspirin for the stomach

Current status: One of the most widely used painkillers worldwide.

3. Serratiopeptidase (Serrapeptase)

Discovered: 1960s in Japan

Source: A proteolytic enzyme originally isolated from Serratia marcescens bacteria in the intestine of silkworms.

Purpose:

Reduces inflammation

Helps break down inflammatory proteins

Reduces swelling and promotes healing

Widely used in India, Japan, and parts of Europe for postoperative swelling and musculoskeletal inflammation.

History of Combining These Three Ingredients

By the early 2000s, pharmaceutical companies began combining:

NSAID (aceclofenac)

Analgesic/antipyretic (paracetamol)

Anti-inflammatory enzyme (serratiopeptidase)

Purpose: create a multi-mechanism pain reliever for faster relief in:

muscle pain

joint pain

post-injury swelling

postoperative inflammation

Sustained-release (SR) versions like Zuno-SR came later to provide longer-lasting pain control with fewer doses.