-5%
Glipita is prescribed to help control blood sugar levels in adults with type 2 diabetes, in combination with diet and exercise.
It can be used alone (monotherapy) or with other diabetes medications.
⚠️ Not suitable for:
- Type 1 diabetes
- Diabetic ketoacidosis (DKA)
- Patients with a history of pancreatitis (risk not established)
Sitagliptin works by inhibiting DPP-4, an enzyme that breaks down incretin hormones (GLP-1 & GIP). These hormones:
Stimulate insulin release when blood sugar is high
Suppress glucagon secretion, reducing glucose production by the liver
By preserving incretin levels, Sitagliptin enhances glucose-dependent insulin release and glucagon suppression—helping regulate blood sugar more effectively.
It selectively inhibits DPP-4 and does not affect DPP-8 or DPP-9 at therapeutic doses.