Nervion 2.5
Nervion 2.5 Original price was: 120.00৳ .Current price is: 114.00৳ .
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Neugalin 150mg Capsule
Neugalin 150mg Capsule Original price was: 301.10৳ .Current price is: 286.05৳ .
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Nervion 5

SKU: 1325

Manufacturer: ACI Limited

Generic: Mirogabalin Besylate

Type: Tablet

Pack Size: 10 Pcs

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Description

Mirogabalin is a derivative of gamma-amino acids that selectively binds to the α2δ subunits of voltage-gated calcium channels (VGCCs). This binding reduces calcium influx at presynaptic terminals, thereby suppressing neurotransmitter release and decreasing hyperexcitability of central nervous system (CNS) neurons.

Absorption: Rapidly absorbed; peak plasma concentration within 0.5–1.5 hours.

Distribution: Volume of distribution: 64–88 L; plasma protein binding ~25%.

Metabolism: Mainly excreted unchanged by the kidneys (61–72%). A minor portion (13–20%) undergoes metabolism via UGT isoforms.

Elimination: Half-life 2–4.9 hours. About 99% is eliminated through urine; ~1% via feces.

Nervion is prescribed for the management of various neuropathic pain conditions, including:

  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Postherpetic Neuralgia (PHN)
  • Peripheral Neuropathic Pain (PNP)

Pregnancy: Use only if benefits outweigh risks. Animal studies show placental transfer.

Lactation: Excretion into breast milk observed in animals; weigh benefits of treatment vs. breastfeeding.