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Nervion 2.5

SKU: 144309

Manufacturer: ACI Limited

Generic: Mirogabalin Besylate

Type: Tablet

Pack Size: 10 Pcs

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Description

Nervion is prescribed for the management of various neuropathic pain conditions, including:

  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Postherpetic Neuralgia (PHN)
  • Peripheral Neuropathic Pain (PNP)

Mirogabalin is a derivative of gamma-amino acids that selectively binds to the α2δ subunits of voltage-gated calcium channels (VGCCs). This binding reduces calcium influx at presynaptic terminals, thereby suppressing neurotransmitter release and decreasing hyperexcitability of central nervous system (CNS) neurons.

Absorption: Rapidly absorbed; peak plasma concentration within 0.5–1.5 hours.

Distribution: Volume of distribution: 64–88 L; plasma protein binding ~25%.

Metabolism: Mainly excreted unchanged by the kidneys (61–72%). A minor portion (13–20%) undergoes metabolism via UGT isoforms.

Elimination: Half-life 2–4.9 hours. About 99% is eliminated through urine; ~1% via feces.