-5%
Maxrin D Capsule is indicated for:
- Treatment of moderate to severe symptoms of Benign Prostatic Hyperplasia (BPH)
- Reducing the risk of acute urinary retention and the need for BPH-related surgical intervention in patients with moderate to severe symptoms
Maxrin D is a fixed-dose combination of Tamsulosin Hydrochloride and Dutasteride, two agents with complementary mechanisms that target both the dynamic and static components of BPH, leading to improved urinary flow and symptom relief.
Tamsulosin
Tamsulosin is a selective alpha-1 adrenergic receptor blocker that acts primarily on smooth muscle in the prostate and bladder neck. Inhibiting these receptors, it relaxes the prostatic and bladder neck smooth muscle, thereby reducing urinary obstruction and improving urine flow.
Tamsulosin shows selectivity for alpha-1A and alpha-1D receptor subtypes, which are predominantly located in the prostate and bladder. Blockade of these receptors is believed to reduce bladder overactivity and alleviate storage symptoms such as urgency and frequency, while minimizing vascular effects associated with alpha-1B receptor inhibition.
Dutasteride
Dutasteride is a synthetic 4-azasteroid and a potent, competitive inhibitor of both Type I and Type II 5-alpha reductase isoenzymes. These enzymes are responsible for converting testosterone into dihydrotestosterone (DHT), the hormone that drives prostate enlargement.
By significantly reducing DHT levels, Dutasteride decreases prostate volume and addresses the underlying cause of BPH. It does not bind to androgen receptors and dissociates slowly from the enzyme complex, resulting in sustained suppression of DHT.