Laclose 3.4gm Oral Solution

Indications

Constipation (Chronic Constipation): In all cases of chronic constipation, the initial therapy should include a fiber-rich diet (vegetables, salads, fruits, etc.), enough of liquids, and plenty of physical activity. Lactulose should only be used if these other treatments are ineffective.

Disruptions in the intestinal flora:

In the case of intestinal flora damage (e.g. following long-term antibiotic treatment)

gallbladder disorders

gastrointestinal disorders ( Colitis, Diverticulosis, Megacolon)

Ammonia levels in the blood have risen (hyper ammonia in hepatopathy, portal-systemic encephalopathy)

Pharmacology

Lactulose is a man-made disaccharide. Lactulose is digested in the colon by saccharolytic bacteria, which produces low molecular weight organic acids (mostly lactic acid), which lowers the pH of the colon contents, promotes water retention via an osmotic action, and therefore increases peristaltic activity. Because lactulose is minimally absorbed, the pharmacokinetics of the absorbed substance are unimportant to the primary therapeutic effect.

Dosage & Administration

In constipation ( chronic constipation):

Adults: Initially 3-6 tea spoons daily, In long-term therapy 1½-6 tea-spoons daily

Children up to 14 years: Initially 3 tea spoons daily, In long-term therapy 1-2 tea-spoons daily

Infants and toddlers: Initially 1-2 tea spoons daily, In long-term therapy 1 tea-spoon daily

In damaged intestinal flora:

Adults: 1-2 tea-spoons daily

Children: 1 tea-spoon daily

For reduction of blood ammonia level:

Hyper-ammonium in hepatopathy: a maximum of 18-30 teaspoons daily.

In portal-systemic encephalopathy: hourly doses of 6-9 tea spoons of Lactulose solution may be used to induce rapid laxation. When the laxative effect has been achieved, the dose may then be reduced.

Interaction

There are no known medication interactions with lactulose. In misuse, potassium deprivation can amplify the glycosidic action of cardiac glycosides.

Contraindications

Galactose and/or lactose hypersensitivity; galactose-free diet, gastro-cardial symptom complex, possible intestinal obstruction.

Side Effects

Flatulence, cramping, and stomach pain may occur at the start of therapy; this is quickly alleviated by lowering the dosage. Diarrhea can occur as a result of an overdose. Electrolyte loss occurs with abuse (primarily potassium).

Pregnancy & Lactation

Flatulence, cramping, and stomach pain may occur at the start of therapy; this is quickly alleviated by lowering the dosage. Diarrhea can occur as a result of an overdose. Electrolyte loss occurs with abuse (primarily potassium).

Precautions & Warnings

Lactulose should be provided with caution to individuals who are lactulose intolerant. The dose used in the treatment of (pre) coma hepatic is generally significantly greater, and diabetics should be aware of this.

Storage Conditions

Keep away from light and heat in a dry area. Keep out of children’s reach.