-5%
Cilnidipine, a dihydropyridine calcium-channel blocker, works by binding to dihydropyridine sites on L-type voltage-dependent calcium channels, reducing calcium ion (Ca²⁺) influx into vascular smooth muscle cells. This action relaxes vascular smooth muscle and induces vasodilation. Additionally, Cilnidipine inhibits Ca²⁺ influx via N-type voltage-dependent calcium channels in sympathetic nerve cell membranes, reducing norepinephrine release from nerve terminals. This dual action may prevent the reflexive increase in heart rate often associated with blood pressure reduction.
- Helps control blood pressure consistently throughout the day.
- Reduces the risk of complications associated with uncontrolled high blood pressure, such as heart attack, stroke, and kidney damage.
- Works on both blood vessels and nerve pathways to help prevent sudden spikes in blood pressure.
- Supports long-term cardiovascular health by reducing strain on the heart and blood vessels.
- Helps protect kidney function in people with high blood pressure and diabetes.
- Is less likely to cause troublesome ankle swelling or a racing heartbeat compared with some older blood pressure medicines.
- Makes it easier to stay on treatment and maintain normal daily activities comfortably.