-5%
Gemifloxacin, the active ingredient in Flogem, belongs to the fluoroquinolone class of antibiotics. It works by inhibiting bacterial DNA synthesis through the inhibition of type II topoisomerases, such as DNA gyrase and topoisomerase IV, which are essential for bacterial growth.
Gemifloxacin is rapidly absorbed after oral intake and is well-distributed in the body, especially in lung tissues (epithelial lining fluid, alveolar macrophages, bronchial tissue) and nasal secretions.
- Excretion: Approximately 36% is excreted through urine and 61% through feces as unchanged drugs or metabolites.
- Gender does not significantly affect drug levels; therefore, no dose adjustment is needed based on gender.
Flogem is prescribed as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It is used to treat bacterial infections in adults caused by susceptible bacteria, including:
- Acute bacterial exacerbation of chronic bronchitis – caused by Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, or Moraxella catarrhalis.
- Community-acquired pneumonia (mild to moderate severity) – caused by Streptococcus pneumoniae (including multi-drug resistant strains), Haemophilus influenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, and Chlamydia pneumoniae.