-2%
Nabuflex 500 mg (nabumetone) is a naphthylalkanone non-steroidal anti-inflammatory drug (NSAID). It acts as a non-selective cyclooxygenase (COX-1 and COX-2) inhibitor, thereby suppressing prostaglandin synthesis. Prostaglandins play a key role in mediating inflammation, pain, fever, and platelet aggregation.
Nabuflex is administered as a prodrug, which undergoes hepatic metabolism to its active form, 6-methoxy-2-naphthylacetic acid (6-MNA). This metabolite is a potent inhibitor of prostaglandin synthesis and is primarily responsible for the drug’s analgesic, anti-inflammatory, and antipyretic effects.
Nabuflex 500 mg is prescribed for the symptomatic management of osteoarthritis and rheumatoid arthritis. Before initiating therapy, the expected therapeutic benefits should be carefully weighed against potential risks. Treatment should always be initiated at the lowest effective dose and continued for the shortest duration necessary to achieve individual patient goals.