Moxigen D Eye Drop 5ml

Moxifloxacin & Dexamethasone Eye Drops are indicated for:

• Treatment of eye infections caused by susceptible microorganisms.
• Prevention of inflammation and bacterial infections that may occur after eye surgery.

Composition

Each ml contains:

• Moxifloxacin Hydrochloride BP equivalent to Moxifloxacin 5 mg
• Dexamethasone Sodium Phosphate USP equivalent to Dexamethasone Phosphate 1 mg

Pharmacology

Moxifloxacin:

• Broad-spectrum 4th generation fluoroquinolone.
• Inhibits topoisomerase II (DNA gyrase) and topoisomerase IV, essential for bacterial DNA replication.

Dexamethasone:

• Cortisone derivative with anti-allergic, anti-exudative, and anti-proliferative properties.
• Inhibits phospholipase A2 and reduces prostaglandin synthesis.
• Suppresses chemotactic infiltration of neutrophils, reducing inflammation.

Dosage & Administration

Prevention of Infection and Post-surgical Ocular Inflammation:

• Instill 1 drop, 4 times a day, in the eye to be operated, from 1 day before surgery until 15 days after surgery.

Cataract Surgery:

• Instill immediately after surgery on the day of the procedure.

LASIK Refractive Surgery:

• Instill at least 15 minutes after surgery on the day of the procedure.

Eye Infections caused by Susceptible Microorganisms:

• Instill 1 drop, 4 times a day, for up to 7 days.

Contraindications

• Hypersensitivity to other quinolones or any components of the product.
• Glaucoma or ocular diseases causing corneal or scleral thinning.
• Viral, fungal, or mycobacterial infections of the eye.

Side Effects

Moxifloxacin:

• Conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, hyperemia, pain, subconjunctival hemorrhage, tearing.

Dexamethasone:

• Visual acuity and field defects, cataract formation, secondary ocular infections, perforation of the globe.

Pregnancy & Lactation

• Use during pregnancy only if benefits outweigh risks; caution during breastfeeding due to potential risks to the infant.

Precautions & Warnings

• Discontinue if allergic reaction occurs.
• Prolonged use may lead to ocular hypertension, glaucoma, cataract formation, or increased risk of secondary infections.
• Evaluate intraocular pressure regularly during treatment.
• Use cautiously in conditions causing corneal or scleral thinning.

Use in Special Populations

• No dosage adjustment needed for elderly patients.
• Safety and efficacy in pediatric patients have not been established.

Overdose Effects

• Information on overdosage in humans is not available.

Therapeutic Class

• Ophthalmic steroid preparations.

Storage Conditions

• Store below 30°C, protected from light.
• Use within 28 days after opening.
• Keep out of reach of children.