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Doxofylline belongs to a group of medicines called bronchodilators. It is used to prevent and manage symptoms of asthma and COPD.
Doxofylline relaxes the airway muscles and widens the air passages in the lungs, making breathing easier. It also has cough-suppressing (antitussive) properties, which help reduce coughing.
Doxophylline is a newer-generation bronchodilator that differs structurally from theophylline due to the presence of a dioxolane group at position 7. This structural modification allows doxophylline to selectively inhibit phosphodiesterase-4 (PDE-4), resulting in relaxation of bronchial smooth muscle and improved airflow.
Unlike theophylline, doxophylline has lower affinity for adenosine A1 and A2 receptors, which contributes to its improved safety profile and reduced cardiovascular side effects. Additionally, doxophylline inhibits platelet-activating factor (PAF) and suppresses leukotriene production, further supporting its anti-inflammatory and bronchodilatory effects.