-5%
Calcium Folinate is metabolized into 5-methyltetrahydrofolate, which:
- Neutralizes Methotrexate Effects: Supplies the cofactor blocked by methotrexate.
- Enhances Fluorouracil Activity: Stabilizes the binding of 5-dUMP with thymidylate synthetase.
- Counteracts Folic Acid Antagonists: Neutralizes toxic effects of methotrexate while enhancing 5-fluorouracil efficacy.
Foly 15mg contains Calcium Folinate, which is essential for the synthesis of purine and pyrimidine, aiding in the production of blood and its components. It serves as a coenzyme in numerous metabolic systems and is especially effective in countering the toxicity of methotrexate and in treating folate deficiency-related conditions.
- Colorectal Cancer: As an adjunct to enhance the efficacy of fluorouracil.
- Methotrexate Toxicity: Antidote to prevent or reverse toxicity caused by methotrexate.
- Megaloblastic Anemia: Particularly anemia caused by folate deficiency.
