-2%
Formet is indicated for the management of type 2 diabetes mellitus, particularly in overweight patients when diet and exercise alone fail to provide adequate glycaemic control.
- Adults: May be used as monotherapy or in combination with other oral antidiabetic agents or insulin.
- Children (≥10 years) and adolescents: May be used alone or together with insulin.
Elderly: Start with lower doses and monitor renal function regularly.
Children (10–12 years): Use with caution; monitor growth and puberty during therapy.
Clinical studies have shown that metformin, as first-line therapy in overweight type 2 diabetic patients, helps reduce the risk of diabetic complications.
Metformin is a biguanide that lowers both fasting and postprandial blood glucose levels without causing hypoglycemia. Its mechanism of action includes:
- Inhibition of hepatic glucose production (gluconeogenesis)
- Reduction in intestinal glucose absorption
- Enhancement of insulin sensitivity and peripheral glucose uptake