-5%
Polymyxin B Sulfate is used for treating infections caused by susceptible organisms, including meningitis.
- IV (Intravenous): Dilute 500,000 units in 300–500 mL of Dextrose 5% (D5W). Infuse over 60–90 minutes.
- IM (Intramuscular): Reconstitute the vial with 2 mL of sterile water for injection (SWI), normal saline (NS), or 1% procaine hydrochloride. Inject deeply into the upper outer quadrant of the gluteal muscle.
- IT (Intrathecal): Reconstitute with 10 mL of NS. Do not use procaine HCl for intrathecal administration.
Polymyxin B targets the phospholipids in the bacterial membrane of gram-negative organisms, compromising membrane integrity and causing intracellular contents to leak, ultimately killing the bacteria.