-5%
Nalidixin is prescribed for the treatment of urinary tract infections (UTIs) caused by susceptible Gram-negative bacteria, including:
- Proteus species
- Klebsiella species
- Enterobacter species
- Escherichia coli
Nalidixic acid is a synthetic antibacterial agent with a narrow spectrum of activity. It can act as either bacteriostatic or bactericidal, depending on the concentration. The drug inhibits bacterial DNA synthesis, likely by interfering with DNA polymerization.
- Absorption: Rapid and complete absorption from the gastrointestinal (GI) tract.
- Distribution: Parent drug and active metabolites reach most tissues, particularly the kidneys and urinary system.
- Elimination:
- Normal renal function: Half-life of 1.1 to 2.5 hours.
- Impaired renal function: Half-life extends up to 21 hours.
- Excretion: Rapid and nearly complete within 24 hours.