-5%
Numira Tablet is prescribed for the management of:
- Neuropathic pain
- Diabetic peripheral neuropathic pain (DPNP)
- Postherpetic neuralgia (PHN)
- Peripheral neuropathic pain (PNP)
Mirogabalin belongs to the gamma-aminobutyric acid derivative class. It selectively binds to α2δ subunits of voltage-gated calcium channels (VGCCs), reducing calcium influx and neurotransmitter release at presynaptic nerve endings. This mechanism decreases central nervous system (CNS) hyperexcitability, thereby alleviating neuropathic pain.
Absorption: Rapid after oral administration (Tmax: 0.5–1.5 hrs)
Protein binding: ~25% (low)
Distribution volume: 64–88 L
Elimination: Mainly excreted unchanged (61–72%) via the kidneys; 13–20% metabolized by UGT enzymes
Half-life: 2–4.9 hours
Excretion: ~99% through urine, ~1% via feces
