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Prebichol 10 Tablet is used for the treatment of primary biliary cirrhosis (also known as primary biliary cholangitis), an autoimmune disease that damages the bile ducts in the liver. This condition leads to a build-up of bile, causing liver damage. Prebichol 10 contains Obeticholic acid, which helps improve liver function by reducing bile production and accumulation in the liver, enhancing bile removal, and reducing inflammation, thus assisting in managing primary biliary cirrhosis.
Treatment Options for Biliary Cirrhosis:
Ursodeoxycholic Acid (UDCA): Commonly known as ursodiol (e.g., Urso, Actigall), this medication helps move bile through the liver, improving liver function and reducing scarring of liver tissue.
Obeticholic Acid (Ocaliva): When used in combination with ursodiol for about a year, obeticholic acid has been shown to improve liver function, especially in patients with primary biliary cirrhosis.
Fibrates (e.g., Tricor): These medications can reduce itching and inflammation of the liver when used alongside UDCA.
Other Medications:
- Colchicine (Colcrys) and Methotrexate (Trexall) can be used to treat the disease.
- Cholestyramine (Questran) and Rifampin (Rifadin) can help relieve itching.
- Opioid antagonists containing naloxone (e.g., Evzio, Bunavail) can also aid in managing itching.
- For fatigue, medications like Modafinil (Provigil) may be prescribed.
- Saliva substitutes and artificial tears can be used to treat dry mouth and dry eyes.
Liver Transplant: If medications do not provide sufficient relief or if liver function significantly declines, a liver transplant may be considered to slow liver damage and extend the patient’s life.
Eligibility for Treatment:
Individuals showing symptoms like excessive itching, persistent fatigue, and long spells of dry mouth and dry eyes should consider getting diagnostic tests done.
Blood tests to examine cholesterol levels, liver enzyme levels, and antibodies can help confirm a diagnosis.
If the tests confirm primary biliary cirrhosis, the individual may be eligible for treatment. The treatment aims to manage symptoms, improve liver function, and slow down liver damage.