-5%
Sibalyn Cream (Silver Sulfadiazine)
- Topical prophylaxis against bacterial colonization and infection in burn wounds.
- Antibacterial management of contaminated or infection-prone wounds, other than burns.
Silver Sulfadiazine has broad-spectrum antibacterial activity. Its exact mechanism is not fully defined, but evidence suggests:
Structural changes in bacterial cell membranes and weakening of the cell wall.
The silver moiety binds to bacterial DNA, preventing replication and proliferation.
The sulfadiazine moiety contributes a bacteriostatic effect.
Selectivity is maintained because mammalian cells contain higher DNA content, reducing the risk of impaired epithelial regeneration.
Absorption of sulfadiazine through burn wounds can occur, especially in extensive burns; up to 10% may be absorbed in adults and excreted in urine.