-5%
Torsem is prescribed for managing edema associated with heart failure, chronic kidney disease, or liver cirrhosis. It is also effective in treating hypertension, either on its own or in combination with other antihypertensive agents.
Torasemide, a loop diuretic, works by inhibiting the Na⁺/K⁺/2Cl⁻ cotransport system located in the thick ascending limb of the loop of Henle. This action blocks sodium and chloride reabsorption, increasing urinary output of sodium, chloride, and water. It indirectly promotes potassium loss by enhancing sodium delivery to the distal tubules. While it significantly boosts diuresis, torasemide does not markedly affect glomerular filtration rate, renal plasma flow, or acid-base balance. Its antihypertensive effect stems from the reduction in extracellular fluid and plasma volume, leading to decreased cardiac output and blood pressure.