-2%
Tacrolimus, a macrolide immunomodulator derived from Streptomyces tsukubaensis, functions by inhibiting T-cell activation. It binds to the intracellular protein FKBP-12, forming a complex that blocks calcineurin activity, thereby suppressing the transcription of pro-inflammatory cytokines and downregulating the immune response.
Vitilimus Ointment is indicated for the short-term and intermittent long-term treatment of moderate to severe atopic dermatitis, particularly in patients who cannot tolerate or are unresponsive to conventional therapies due to potential risks.
Additionally, it is used in managing other chronic skin conditions including:
- Chronic cutaneous graft-versus-host disease
- Hand and foot eczema
- Allergic contact dermatitis
- Vitiligo
- Psoriasis
- Lichen planus
- Facial lichen
- Vulvar lichen sclerosus
- Pyoderma gangrenosum
- Leg ulcers in rheumatoid arthritis
- Steroid-induced rosacea
- Alopecia areata
- Annular erythema
- Chronic actinic dermatitis
- Recalcitrant facial erythema