-5%
Prucon is indicated for the symptomatic management of chronic constipation in adults who do not respond adequately to conventional laxatives.
Prucalopride is a highly selective 5-HT4 receptor agonist, with no significant interaction with hERG channels or 5-HT1 receptors—reducing cardiovascular risks associated with older drugs of this class.
5-HT4 receptors are distributed throughout the GI tract, particularly in smooth muscle cells, enterochromaffin cells, and the myenteric plexus.
Their stimulation enhances acetylcholine release, the primary excitatory neurotransmitter of the gut.
This action increases colonic motility by promoting contraction of longitudinal muscle and relaxation of circular muscle, facilitating forward propulsion of intestinal contents.